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Journal article

Activation of the immune-metabolic receptor GPR84 enhances inflammation and phagocytosis in macrophages

Abstract:

GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is involved in the inflammatory response, but the mechanisms by which it modulates inflammation have been incompletely described. In this study, we investigated GPR84 expression, activation, and function in macrophages to establish the role of the receptor during the inflammatory response. We observed that GPR84 expression in murine tissue...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More from this funder
Name:
Diabetes UK
Grant:
15/0005171
More from this funder
Name:
Wellcome Trust
Grant:
238
More from this funder
Name:
British Heart Foundation
Grant:
RE/13/1/30181
More from this funder
Name:
Novo Nordisk Fonden
Grant:
NNF15CC0018346
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
9
Issue:
JUN
Pages:
1419
Publication date:
2018-06-20
Acceptance date:
2018-06-06
DOI:
EISSN:
1664-3224
ISSN:
1664-3224
Keywords:
Pubs id:
pubs:858734
UUID:
uuid:e8c8ebe3-aa28-4074-b277-7e6906394da6
Local pid:
pubs:858734
Deposit date:
2018-07-03

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