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Colicin-mediated transport of DNA through the iron transporter FepA

Abstract:

Colicins are protein antibiotics deployed by Escherichia coli to eliminate competing strains. Colicins frequently exploit outer membrane (OM) nutrient transporters to penetrate the selectively permeable bacterial cell envelope. Here, by applying live-cell fluorescence imaging, we were able to monitor the entry of the pore-forming toxin colicin B (ColB) into E. coli and localize it within the periplasm. We further demonstrate that single-stranded DNA coupled to ColB can also be transported to ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/mbio.01787-21

Authors


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Role:
Author
ORCID:
0000-0001-5721-0381
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Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/P009948/1
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Name:
US National Institutes of Health
Publisher:
American Society for Microbiology
Journal:
mBio More from this journal
Volume:
12
Issue:
5
Article number:
e01787-21
Publication date:
2021-09-21
Acceptance date:
2021-08-23
DOI:
EISSN:
2150-7511
Pmid:
34544275
Language:
English
Keywords:
Pubs id:
1196761
Local pid:
pubs:1196761
Deposit date:
2021-11-22

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