- Abstract:
-
In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control of viremia. Despite these responses, 70-80% of individuals develop persistent infection. Although viral escape from CD8 responses has been illustrated in the chimpanzee model of HCV infection, the effect of CD8 selection pressure on viral evolution and containment in acute HCV infection in humans remains unclear. Here, we examined viral...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20041006
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 200
- Issue:
- 12
- Pages:
- 1593-1604
- Publication date:
- 2004-12-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:e8bde6ac-a2ed-4fc1-9232-8c719436935a
- Source identifiers:
-
14072
- Local pid:
- pubs:14072
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
CD8 epitope escape and reversion in acute HCV infection.
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