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Journal article

CD8 epitope escape and reversion in acute HCV infection.

Abstract:

In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control of viremia. Despite these responses, 70-80% of individuals develop persistent infection. Although viral escape from CD8 responses has been illustrated in the chimpanzee model of HCV infection, the effect of CD8 selection pressure on viral evolution and containment in acute HCV infection in humans remains unclear. Here, we examined viral...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20041006

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Journal:
The Journal of experimental medicine
Volume:
200
Issue:
12
Pages:
1593-1604
Publication date:
2004-12-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:e8bde6ac-a2ed-4fc1-9232-8c719436935a
Source identifiers:
14072
Local pid:
pubs:14072

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