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Journal article

Oxygen sensors and angiogenesis.

Abstract:

Local oxygen tension has a profound effect on the vasculature, which compensates vascular insufficiency through the induction of angiogenesis. An important mediator in this process is the hypoxia-inducible factor (HIF) complex, which is activated in hypoxic cells and increases transcription of a broad range of genes including angiogenic growth factors such as VEGF. HIF is primarily regulated through oxygen-dependent proteasomal destruction of the regulatory subunit, HIF-1 alpha or HIF-2 alpha...

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Publication status:
Published

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Publisher copy:
10.1006/scdb.2001.0287

Authors


Maxwell, PH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Journal:
Seminars in cell and developmental biology
Volume:
13
Issue:
1
Pages:
29-37
Publication date:
2002-02-05
DOI:
EISSN:
1096-3634
ISSN:
1084-9521
URN:
uuid:e8bc8883-9e88-4f11-a620-9379e1bcaa03
Source identifiers:
3618
Local pid:
pubs:3618

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