Journal article icon

Journal article

Synthesis of novel enantiopure fluorinated building blocks from acyclic chiral allylsilanes.

Abstract:

[reaction: see text] Homochiral beta-fluorinated gamma,delta-unsaturated carboxylic acids with an allylic fluorinated stereogenic center are available from the corresponding enantiopure allylsilanes. The key step for introduction of the fluorine substituent is an electrophilic fluorodesilylation reaction carried out in the presence of Selectfluor. Reduction of the resulting beta-fluorinated pentenoic acid into the corresponding fluorinated alcohol was also performed leading to the formation o...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/ol0518535

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Organic letters More from this journal
Volume:
7
Issue:
20
Pages:
4495-4497
Publication date:
2005-09-01
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Language:
English
Pubs id:
pubs:33241
UUID:
uuid:e8af457c-5464-40ef-aa64-0bce39e6c52a
Local pid:
pubs:33241
Source identifiers:
33241
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP