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Rare variants in MYD88, IRAK4 and IKBKG and susceptibility to invasive pneumococcal disease : a population-based case-control study

Abstract:

Although rare variants within the Toll-like receptor signalling pathway genes have been found to underlie human primary immunodeficiencies associated with selective predisposition to invasive pneumococcal disease (IPD), the contribution of variants in these genes to IPD susceptibility at the population level remains unknown. Complete re-sequencing of IRAK4, MYD88 and IKBKG genes was undertaken in 164 IPD cases from the UK and 164 geographically-matched population-based controls. 233 single-nu...

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Publication status:
Published
Peer review status:
Peer reviewed

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
090532/Z/09/Z
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
10
Issue:
4
Publication date:
2015-04-17
Acceptance date:
2015-02-19
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:e8a9a29d-f709-46d3-839c-f4a0b5d65816
Deposit date:
2015-05-28

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