Safety reporting and adverse-event profile of mirtazapine described in randomized controlled trials in comparison with other classes of antidepressants in the acute-phase treatment of adults with depression: systematic review and meta-analysis.

Journal article

BACKGROUND: Mirtazapine has a unique mechanism of antidepressant action, and thus is thought to have a different profile of adverse events from that of other antidepressants. OBJECTIVE: To present a methodologically rigorous systematic review of the adverse event profile of mirtazapine and point to possible problems with safety reporting in randomized controlled trials (RCTs) of the acute-phase treatment of major depression in adults with mirtazapine in comparison with other types of antidep...

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Authors: Watanabe, N; Omori, I; Nakagawa, A; Cipriani, A; Barbui, C

• Publication status: Published
• Journal: CNS drugs
• Volume: 24
• Issue: 1
• Pages: 35-53
• Publication date: 2010-01-01
• DOI: 10.2165/11319480-000000000-00000
• ISSN: 1172-7047
• Language: English
• Keywords: Antidepressive Agents, Tricyclic; Adult; Randomized Controlled Trials as Topic; Adverse Drug Reaction Reporting Systems; MANGA (Meta-Analysis of New Generation Antidepressants) Study Group; Regression Analysis; Mianserin; Humans; Depressive Disorder, Major