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Journal article

Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

Abstract:

BACKGROUND: Aldosterone is an important cardiovascular hormone; 15% of hypertensive subjects have alteration in aldosterone regulation, defined by a raised ratio of aldosterone to renin (ARR). Studies of the aldosterone synthase gene (CYP11B2) have focused on a single nucleotide polymorphism in the 5'promoter region (-344 C/T). In normotensive subjects, the T allele associates with raised levels of the 11-deoxysteroids, deoxycorticosterone and 11-deoxycortisol which are substrates for 11beta-...

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Publication status:
Published

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Journal:
Clinical endocrinology
Volume:
67
Issue:
6
Pages:
832-838
Publication date:
2007-12-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:e8942765-1b3a-40ae-a51b-62943cd7218e
Source identifiers:
105265
Local pid:
pubs:105265

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