Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

Journal article

BACKGROUND: Aldosterone is an important cardiovascular hormone; 15% of hypertensive subjects have alteration in aldosterone regulation, defined by a raised ratio of aldosterone to renin (ARR). Studies of the aldosterone synthase gene (CYP11B2) have focused on a single nucleotide polymorphism in the 5'promoter region (-344 C/T). In normotensive subjects, the T allele associates with raised levels of the 11-deoxysteroids, deoxycorticosterone and 11-deoxycortisol which are substrates for 11beta-...

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Authors: Freel, E; Ingram, M; Friel, E; Fraser, R; Brown, M

• Publication status: Published
• Journal: Clinical endocrinology
• Volume: 67
• Issue: 6
• Pages: 832-838
• Publication date: 2007-12-01
• DOI: 10.1111/j.1365-2265.2007.02971.x
• EISSN: 1365-2265
• ISSN: 0300-0664
• Language: English
• Keywords: Aldosterone; Humans; Middle Aged; Aged; Alleles; Steroid 11-beta-Hydroxylase; Female; Adrenocorticotropic Hormone; Genotype; Polymorphism, Single Nucleotide; Aldosterone Synthase; Cortodoxone; Hypertension; Male