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Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Abstract:

Mutations within cytotoxic T lymphocyte (CTL) epitopes impair T cell recognition, but escape mutations arising in flanking regions that alter antigen processing have not been defined in natural human infections. In human histocompatibility leukocyte antigen (HLA)-B57+ HIV-infected persons, immune selection pressure leads to a mutation from alanine to proline at Gag residue 146 immediately preceding the NH2 terminus of a dominant HLA-B57-restricted epitope, ISPRTLNAW. Although N-extended wild-...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20031982

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Journal:
The Journal of experimental medicine
Volume:
199
Issue:
7
Pages:
905-915
Publication date:
2004-04-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:e87c5ff4-f49f-4fb4-b39c-aeda80eff1ae
Source identifiers:
130653
Local pid:
pubs:130653

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