Homologous monoclonal antibodies specific for alpha 1-3 dextran stimulate polyclonal proliferation of Lyb-5+ B cells.

Journal article

In this paper we describe the polyclonal blast response induced in nonimmune murine splenocytes by two homologous alpha 1-3 dextran-binding myeloma protein, J558 and MOPC104E. This stimulation appears to be independent of MHC or IgCh gene complex control, and proceeds entirely in a T-dependent fashion. The responding B cell population appears to belong to the more mature Lyb-5+ subset. This response was elicited by several independently prepared batches of J558 and MOPC104E, each of which was...

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Authors: Victor-Kobrin, C; Bikoff, E; Bona, C

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 134
• Issue: 6
• Pages: 3686-3692
• Publication date: 1985-06-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Lymphocyte Activation; Antibodies, Monoclonal; Mice, Nude; Mice, Inbred C57BL; Male; Mice, Inbred C3H; Mice, Inbred BALB C; Female; B-Lymphocytes; Antigens, T-Independent; Mice; Antibody Specificity; Immunologic Deficiency Syndromes; Endotoxins; Animals; Dextrans; Binding Sites, Antibody; Mice, Inbred CBA; Interphase; Myeloma Proteins; Antigens, Ly