Dyspnea-related cues engage the prefrontal cortex: evidence from functional brain imaging in COPD.
Dyspnea is the major source of disability in COPD. In COPD, environmental cues (eg, the prospect of having to climb stairs) become associated with dyspnea and may trigger dyspnea even before physical activity commences. We hypothesized that brain activation relating to such cues would be different between patients with COPD and healthy control subjects, reflecting greater engagement of emotional mechanisms in patients.Using functional MRI (FMRI), we investigated brain responses to dyspnea-rel...Expand abstract
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- Peer reviewed
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- Copyright holder:
- The American College of Chest Physicians
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- Copyright © 2015 The American College of Chest Physicians. Published by Elsevier Inc. Open Access funded by Medical Research Council under a Creative Commons license.