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Dyspnea-related cues engage the prefrontal cortex: evidence from functional brain imaging in COPD.

Abstract:

Dyspnea is the major source of disability in COPD. In COPD, environmental cues (eg, the prospect of having to climb stairs) become associated with dyspnea and may trigger dyspnea even before physical activity commences. We hypothesized that brain activation relating to such cues would be different between patients with COPD and healthy control subjects, reflecting greater engagement of emotional mechanisms in patients.Using functional MRI (FMRI), we investigated brain responses to dyspnea-rel...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1378/chest.15-0416

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
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More from this funder
Funding agency for:
Pattinson, KT
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Chest Journal website
Volume:
148
Issue:
4
Pages:
953-961
Publication date:
2013-09-07
DOI:
EISSN:
1931-3543
ISSN:
0012-3692
URN:
uuid:e87393b9-848f-4c58-b5dc-8d0a6db9f2f6
Source identifiers:
531531
Local pid:
pubs:531531

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