Journal article
Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA
- Abstract:
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Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well documented in mammals, its nuclear function remains obscure. Here we show that Dicer is present in both the nucleus and cytoplasm, and its nuclear levels are tightly regulated. Dicer interacts with RNA polymerase II (Pol II) at actively transcribed gene loci. Loss of Dicer causes the appearance of endogenous double-...
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- Publisher copy:
- 10.1038/nsmb.2827
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Bibliographic Details
- Journal:
- Nature Structural and Molecular Biology
- Volume:
- 21
- Issue:
- 6
- Pages:
- 552-559
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Source identifiers:
-
471830
Item Description
- Pubs id:
-
pubs:471830
- UUID:
-
uuid:e86b80d6-6530-4f7f-980d-2edf1485cce4
- Local pid:
- pubs:471830
- Deposit date:
- 2014-08-06
Terms of use
- Copyright date:
- 2014
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