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Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA

Abstract:

Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well documented in mammals, its nuclear function remains obscure. Here we show that Dicer is present in both the nucleus and cytoplasm, and its nuclear levels are tightly regulated. Dicer interacts with RNA polymerase II (Pol II) at actively transcribed gene loci. Loss of Dicer causes the appearance of endogenous double-...

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Publisher copy:
10.1038/nsmb.2827

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Nature Structural and Molecular Biology
Volume:
21
Issue:
6
Pages:
552-559
Publication date:
2014-01-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:e86b80d6-6530-4f7f-980d-2edf1485cce4
Source identifiers:
471830
Local pid:
pubs:471830

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