A unique residue in rab3c determines the interaction with novel binding protein Zwint-1.

Journal article

Exocytic events are tightly regulated cellular processes in which rab GTPases and their interacting proteins perform an important function. We set out to identify new binding partners of rab3, which mediates regulated secretion events in specialized cells. We discovered Zwint-1 as a rab3 specific binding protein that bound preferentially to rab3c. The interaction depends on a critical residue in rab3c that determines the binding efficiency of Zwint-1, which is immaterial for interaction with ...

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Authors: van Vlijmen, T; Vleugel, M; Evers, M; Mohammed, S; Wulf, P

• Publication status: Published
• Journal: FEBS letters
• Volume: 582
• Issue: 19
• Pages: 2838-2842
• Publication date: 2008-08-01
• DOI: 10.1016/j.febslet.2008.07.012
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: Nuclear Proteins; Animals; Molecular Sequence Data; Neurons; Intracellular Signaling Peptides and Proteins; Rats; Mice; Cercopithecus aethiops; Hippocampus; Kinetochores; Synaptosomal-Associated Protein 25; Amino Acid Sequence; COS Cells; Conserved Sequence; rab3 GTP-Binding Proteins; Serine