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Journal article

Structural insights into functional overlapping and differentiation among myosin V motors.

Abstract:

Myosin V (MyoV) motors have been implicated in the intracellular transport of diverse cargoes including vesicles, organelles, RNA-protein complexes, and regulatory proteins. Here, we have solved the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb, and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process, which is unique for the MyoVc subclass. Moreover, the cargo- and ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m113.507202

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Journal:
The Journal of biological chemistry
Volume:
288
Issue:
47
Pages:
34131-34145
Publication date:
2013-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:e86491a4-14ea-4a46-88bc-08c19e887324
Source identifiers:
434346
Local pid:
pubs:434346

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