Journal article icon

Journal article

Structure of the heterodimeric core primase.

Abstract:

Primases are DNA-dependent RNA polymerases that synthesize the oligoribonucleotide primers essential to DNA replication. In archaeal and eukaryotic organisms, the core primase is a heterodimeric enzyme composed of a small and a large subunit. Here we report a crystallographic and biochemical analysis of the core primase from the archaeon Sulfolobus solfataricus. The structure provides the first three-dimensional description of the large subunit and its interaction with the small subunit. The ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nsmb1013

Authors


Lao-Sirieix, SH More by this author
Nookala, RK More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Pellegrini, L More by this author
Journal:
Nature structural and molecular biology
Volume:
12
Issue:
12
Pages:
1137-1144
Publication date:
2005-12-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:e85e8acf-2945-48be-b557-c2159b5e5663
Source identifiers:
28208
Local pid:
pubs:28208

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP