Long-lived memory CD8+ T cells are programmed by prolonged antigen exposure and low levels of cellular activation.

Journal article

CD8+ T cells play a crucial role in controlling intracellular pathogens. The level of memory CD8+ T cells developing after vaccination or infection influences the degree of T cell-mediated protection after secondary infection. We used defined animal models and infections/immunizations by replicating or non-replicating antigens to define on a molecular and cellular level in vivo the parameters that identify and shape long-lived CD8+ T cell memory. We show that the timing of antigen exposure du...

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Authors: Bachmann, M; Beerli, R; Agnellini, P; Wolint, P; Schwarz, K

• Publication status: Published
• Journal: European journal of immunology
• Volume: 36
• Issue: 4
• Pages: 842-854
• Publication date: 2006-04-01
• DOI: 10.1002/eji.200535730
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Antigens; Receptors, Interleukin-7; Gene Expression; Mice, Inbred C57BL; Serpins; Lymphocytic choriomeningitis virus; Animals; Vaccines; Xenopus Proteins; Reverse Transcriptase Polymerase Chain Reaction; Antigens, Viral; Immunologic Memory; Fluorescent Antibody Technique; CD8-Positive T-Lymphocytes; Mice; T-Box Domain Proteins; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Phosphorylation