Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.

Journal article

The ATP-sensitive potassium (K(ATP)) channel exhibits spontaneous bursts of rapid openings, which are separated by long closed intervals. Previous studies have shown that mutations at the internal mouth of the pore-forming (Kir6.2) subunit of this channel affect the burst duration and the long interburst closings, but do not alter the fast intraburst kinetics. In this study, we have investigated the nature of the intraburst kinetics by using recombinant Kir6.2/SUR1 K(ATP) channels heterologou...

Expand abstract

Authors: Proks, P; Capener, C; Jones, P; Ashcroft, F

• Publication status: Published
• Journal: Journal of general physiology
• Volume: 118
• Issue: 4
• Pages: 341-353
• Publication date: 2001-10-01
• DOI: 10.1085/jgp.118.4.341
• EISSN: 1540-7748
• ISSN: 0022-1295
• Language: English
• Keywords: Potassium Channels, Inwardly Rectifying; Ion Channel Gating; Adenosine Triphosphate; Kinetics; Xenopus laevis; Protein Structure, Secondary; Mice; Peptide Fragments; Mutation; Amino Acid Sequence; Animals; Female; Rats; Potassium; Potassium Channels; Electric Conductivity; Molecular Sequence Data; Oocytes