Engagement of major histocompatibility complex class I and class II molecules up-regulates intercellular adhesion of human B cells via a CD11/CD18-independent mechanism.

Journal article

We have studied the role of major histocompatibility complex (MHC) molecules in the regulation of intercellular adhesion of human B cells. We found that molecules able to bind to MHC class II molecules, such as monoclonal antibodies or staphylococcal enterotoxins, induced rapid and sustained homotypic adhesion of Epstein-Barr virus (EBV)-transformed B cell lines as well as peripheral blood B lymphocytes. Moreover, anti-MHC class I monoclonal antibodies also stimulated intercellular adherence....

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Authors: Alcover, A; Juillard, V; Acuto, O

• Publication status: Published
• Journal: European journal of immunology
• Volume: 22
• Issue: 2
• Pages: 405-412
• Publication date: 1992-02-01
• DOI: 10.1002/eji.1830220218
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: B-Lymphocytes; Major Histocompatibility Complex; HLA Antigens; Receptors, Leukocyte-Adhesion; Humans; T-Lymphocytes; HLA-DR Antigens; Lymphocyte Function-Associated Antigen-1; Antigen-Presenting Cells; Antigens, CD; Antigens, CD18; Cell Adhesion; Antigens, CD11