Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides.

Journal article

A range of new carboxylate functionalised bis(thiosemicarbazone) ligands and their Cu(II) complexes have been prepared, fully characterised and radiolabeled in high yield with both (64)Cu and (99m)Tc. Conjugation to a bombesin derivative was achieved using standard solid phase synthetic methodologies and the (64)Cu-labeled conjugate was shown to have good tumour uptake in mice with xenografted PC-3 tumours.

Authors: Hueting, R; Christlieb, M; Dilworth, JR; García Garayoa, E; Gouverneur, V

• Publication status: Published
• Journal: Dalton transactions (Cambridge, England : 2003)
• Volume: 39
• Issue: 15
• Pages: 3620-3632
• Publication date: 2010-04-01
• DOI: 10.1039/b925128f
• EISSN: 1477-9234
• ISSN: 1477-9226
• Language: English
• Keywords: Animals; Mice, Nude; Copper; Ligands; Mice; Transplantation, Heterologous; Coordination Complexes; Electron Spin Resonance Spectroscopy; Peptides; Isotope Labeling; Thiosemicarbazones; Temperature; Chelating Agents; Tissue Distribution; Antineoplastic Agents