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Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides.

Abstract:
A range of new carboxylate functionalised bis(thiosemicarbazone) ligands and their Cu(II) complexes have been prepared, fully characterised and radiolabeled in high yield with both (64)Cu and (99m)Tc. Conjugation to a bombesin derivative was achieved using standard solid phase synthetic methodologies and the (64)Cu-labeled conjugate was shown to have good tumour uptake in mice with xenografted PC-3 tumours.
Publication status:
Published

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Publisher copy:
10.1039/b925128f

Authors


Hueting, R More by this author
Christlieb, M More by this author
Dilworth, JR More by this author
García Garayoa, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Dalton transactions (Cambridge, England : 2003)
Volume:
39
Issue:
15
Pages:
3620-3632
Publication date:
2010-04-05
DOI:
EISSN:
1477-9234
ISSN:
1477-9226
URN:
uuid:e84a8aa8-40cc-46bb-afd7-c5588b62bb44
Source identifiers:
52134
Local pid:
pubs:52134

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