Long-term prognosis after coronary bypass surgery depends on interleukin 6 polymorphism and past acute infections.

Journal article

We were seeking for a mutual link between the -174G>C IL6 promoter polymorphism, history of the past acute respiratory infections and the long-term post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence. Two hundred thirty seven post-CABG patients have been followed up for a median period of 36 months. We found that past acute infections, influenza-like illness and lack of vaccination against influenza confer a significant risk of the post-CABG MACE incidence in the -174G allele carrying patients.

Authors: Myśliwska, J; Wieckiewicz, J; Hak, L; Siebert, J; Rogowski, J

• Publication status: Published
• Journal: International journal of cardiology
• Volume: 118
• Issue: 3
• Pages: 421-422
• Publication date: 2007-06-01
• DOI: 10.1016/j.ijcard.2006.07.092
• EISSN: 1874-1754
• ISSN: 0167-5273
• Language: English
• Keywords: Treatment Outcome; Female; Middle Aged; Coronary Artery Bypass; Interleukin-6; Male; Gene Expression Regulation; Prognosis; Cohort Studies; Postoperative Complications; Respiratory Tract Infections; Risk Assessment; Influenza, Human; Coronary Disease; Comorbidity; Polymorphism, Genetic; Humans; Aged; Acute Disease