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Journal article

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Abstract:

Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioid antidepressants by an uncharacterized, arrestin-independent mechanism. Here we use an iterative, discovery-based proteomic approach to show that following opioid administration, peroxiredoxin 6 (PRDX6) is recruited to the opioid receptor complex by c-Jun N-terminal kinase (JNK) phosphorylation. PRDX6 activation generates reactive oxygen species via NADPH ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-00791-2

Authors


Schattauer, SS More by this author
Reichard, KL More by this author
Abraham, AD More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
ORCID:
0000-0001-9305-1621
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
743
Publication date:
2017-09-29
Acceptance date:
2017-07-27
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:734461
URN:
uri:e7f5c768-a8e9-4e04-999a-e5dfe2b18cd5
UUID:
uuid:e7f5c768-a8e9-4e04-999a-e5dfe2b18cd5
Local pid:
pubs:734461

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