- Subtitle:
- Cannabinoid receptor 2 and immune cell trafficking
- Abstract:
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Activation of the cannabinoid receptor CB2 has been shown to induce directed leukocyte migration and inhibit leukocyte chemotaxis towards CC chemokines. However, the role that CB2 plays in regulating macrophage chemotaxis remains understudied. Using a real-time chemotaxis assay and a panel of chemically diverse CB2 agonists, I set out to examine whether CB2 modulates primary macrophage chemotaxis. Of 14 agonists tested, only a subset acted as
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
- English
- Keywords:
- Subjects:
- Copyright date:
- 2016
Thesis
Assessment of the role of cannabinoid receptor 2 in innate immune cell trafficking during acute inflammation
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