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Journal article

Comparison of next-generation sequencing technologies for comprehensive assessment of full-length hepatitis C viral genomes

Abstract:

Affordable next-generation sequencing (NGS) technologies for hepatitis C virus (HCV) may potentially identify both viral genotype and resistance genetic motifs in the era of directly acting antiviral (DAA) therapies. This study compared the ability of highthroughput NGS methods to generate full-length, deep, HCV sequence data sets and evaluated their utility for diagnostics and clinical assessment. NGS methods using (i) unselected HCV RNA (metagenomics), (ii) preenrichment of HCV RNA by probe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1128/JCM.00330-16

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
National Institutes of Health
Funding agency for:
Klenerman, P
Grant:
U19AI082630
More from this funder
Name:
Wellcome Trust
Funding agency for:
Klenerman, P
Grant:
U19AI082630
More from this funder
Name:
NIHR Biomedical Research Centre
Funding agency for:
Klenerman, P
Grant:
U19AI082630
More from this funder
Name:
Oxford Martin School
Funding agency for:
Ansari, M
Klenerman, P
Grant:
U19AI082630
More from this funder
Name:
Medical Research Council
Funding agency for:
Barnes, E
Grant:
MR/K01532X/1
Publisher:
American Society for Microbiology
Journal:
Journal of Clinical Microbiology More from this journal
Volume:
54
Issue:
10
Pages:
2470-2484
Publication date:
2016-07-06
Acceptance date:
2016-06-28
DOI:
ISSN:
0095-1137 and 1098-660X
Keywords:
Pubs id:
pubs:655287
UUID:
uuid:e7e1216b-f726-4c3d-be99-ffaa635ad903
Local pid:
pubs:655287
Source identifiers:
655287
Deposit date:
2016-11-01

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