Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis

Bella, Á; Arrizabalaga, L; Di Trani, CA; Gonzalez-Gomariz, J; Gomar, C; Russo-Cabrera, JS; Olivera, I; Cirella, A; Fernandez-Sendin, M; Alvarez, M; Teijeira, A; Atay, C; Medina-Echeverz, J; Hinterberger, M; Hochrein, H; Melero, I; Berraondo, P; Aranda, F

Women's Health Collection

Journal article

Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis

Abstract:: Peritoneal metastases remain a significant clinical challenge owing to the immunosuppressive nature of the omentum, which serves as a protective niche for disseminated tumor cells. Our recent study explored the targeted delivery of immunomodulatory cytokine-encoded mRNAs to the omentum, aiming to shift its role from a tumor-supportive site to an immune-activating ally. Our findings highlight the potential of cytokine mRNA delivery as a novel and safe immunotherapeutic strategy for peritoneal metastases

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Bella, Á., Arrizabalaga, L., Di Trani, C. A., Gonzalez-Gomariz, J., Gomar, C., Russo-Cabrera, J. S., Olivera, I., Cirella, A., Fernandez-Sendin, M., Alvarez, M., Teijeira, A., Atay, C., Medina-Echeverz, J., Hinterberger, M., Hochrein, H., Melero, I., Berraondo, P., & Aranda, F. (2023). Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis. Journal for ImmunoTherapy of Cancer, 11(11), e006702–e006702.

MLA Style

Bella, Á, et al. “Intraperitoneal Administration of a Modified Vaccinia Virus Ankara Confers Single-Chain Interleukin-12 Expression to the Omentum and Achieves Immune-Mediated Efficacy against Peritoneal Carcinomatosis.” Journal for ImmunoTherapy of Cancer, vol. 11, no. 11, 2023, pp. e006702–e006702.

Chicago Style

Bella, Á, L Arrizabalaga, CA Di Trani, et al. 2023. “Intraperitoneal Administration of a Modified Vaccinia Virus Ankara Confers Single-Chain Interleukin-12 Expression to the Omentum and Achieves Immune-Mediated Efficacy against Peritoneal Carcinomatosis.” Journal for ImmunoTherapy of Cancer 11 (11): e006702–e006702.
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