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Journal article

Reduced purifying selection prevails over positive selection in human copy number variant evolution.

Abstract:

Copy number variation is a dominant contributor to genomic variation and may frequently underlie an individual's variable susceptibilities to disease. Here we question our previous proposition that copy number variants (CNVs) are often retained in the human population because of their adaptive benefit. We show that genic biases of CNVs are best explained, not by positive selection, but by reduced efficiency of selection in eliminating deleterious changes from the human population. Of four CNV...

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Publication status:
Published

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Publisher copy:
10.1101/gr.077289.108

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Genome research More from this journal
Volume:
18
Issue:
11
Pages:
1711-1723
Publication date:
2008-11-01
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Language:
English
Keywords:
Pubs id:
pubs:237892
UUID:
uuid:e7d3e298-0134-424c-8065-2b862f2c85be
Local pid:
pubs:237892
Source identifiers:
237892
Deposit date:
2012-12-19

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