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The effect of regularly dosed acetaminophen vs no acetaminophen on renal function in plasmodium knowlesi malaria (PACKNOW): a randomized, controlled trial

Abstract:

Background
Acetaminophen inhibits cell-free hemoglobin-induced lipid peroxidation and improves renal function in severe falciparum malaria but has not been evaluated in other infections with prominent hemolysis, including Plasmodium knowlesi malaria.

Methods
PACKNOW was an open-label, randomized, controlled trial of acetaminophen (500 mg or 1000 mg every 6 hours for 72 hours) vs no acetaminophen in Malaysian patients aged ≥5 years...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/cid/ciac152

Authors


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Role:
Author
ORCID:
0000-0002-3643-7605
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Role:
Author
ORCID:
0000-0001-9914-8352
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Institution:
University of Oxford
Role:
Author
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Name:
Australian National Health and Medical Research Council
Publisher:
Oxford University Press
Journal:
Clinical Infectious Diseases More from this journal
Volume:
75
Issue:
8
Pages:
1379-1388
Publication date:
2022-02-18
Acceptance date:
2022-02-13
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pmid:
35180298
Language:
English
Keywords:
Pubs id:
1241386
Local pid:
pubs:1241386
Deposit date:
2023-01-09

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