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Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells

Abstract:

A better understanding of how antibiotic exposure impacts the evolution of resistance in bacterial populations is crucial for designing more sustainable treatment strategies. The conventional approach to this question is to measure the range of concentrations over which resistant strain(s) are selectively favored over a sensitive strain. Here, we instead investigate how antibiotic concentration impacts the initial establishment of resistance from single cells, mimicking the clonal expansion o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1919672117

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Name:
Wellcome Trust
Grant:
106918/Z/15/Z
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
117
Issue:
32
Pages:
19455-19464
Publication date:
2020-07-23
Acceptance date:
2020-06-24
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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