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Thesis

Overexpression of DNA polymerase beta and its effect on genome stability

Abstract:

DNA polymerases play key roles in DNA synthesis by catalysing the polymerisation of deoxynucleotides opposite a parental (template) DNA strand to generate a new or repaired complementary daughter strand. Faithful replication by DNA polymerases is essential in maintaining genome integrity during cell division, DNA repair and DNA recombination. DNA polymerase beta (Pol β) plays a pivotal role in the base excision repair (BER) pathway by performing repair synthesis to fill single nucleotide g...

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Peer review status:
Peer Reviewed

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Department:
University of Oxford
This thesis was digitised thanks to the generosity of Dr Leonard Polonsky More from this funder
Publication date:
2006
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Local pid:
polonsky:4:18

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