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Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

Abstract:

The tumor vascular effects of the tubulin destabilizing agent disodium combretastatinA-4 3-O-phosphate (CA-4-P) were investigated in the rat P22 tumor growing in a dorsal skin flap window chamber implanted into BD9 rats. CA-4-P is in clinical trial as a tumor vascular targeting agent. In animal tumors, it can cause the shut-down of blood flow, leading to extensive tumor cell necrosis. However, the mechanisms leading to vascular shut-down are still unknown. Tumor vascular effects were visualiz...

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Publication status:
Published

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Journal:
Cancer research More from this journal
Volume:
61
Issue:
17
Pages:
6413-6422
Publication date:
2001-09-01
EISSN:
1538-7445
ISSN:
0008-5472
Language:
English
Keywords:
Pubs id:
pubs:131140
UUID:
uuid:e7b3fcae-c3cf-4e9c-becc-59a4f5d2e1cf
Local pid:
pubs:131140
Source identifiers:
131140
Deposit date:
2013-11-16

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