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Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.

Abstract:

Myosin V motor proteins facilitate recycling of synaptic receptors, including AMPA and acetylcholine receptors, in central and peripheral synapses, respectively. To shed light on the regulation of receptor recycling, we employed in vivo imaging of mouse neuromuscular synapses. We found that myosin Va cooperates with PKA on the postsynapse to maintain size and integrity of the synapse; this cooperation also regulated the lifetime of acetylcholine receptors. Myosin Va and PKA colocalized in sub...

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Publisher copy:
10.1073/pnas.0914087107

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
107
Issue:
5
Pages:
2031-2036
Publication date:
2010-02-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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