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Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

Abstract:

Oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor (HIF) by a set of closely related prolyl hydroxylase domain enzymes (PHD1, 2 and 3) regulates a range of transcriptional responses to hypoxia. This raises important questions about the role of these oxygen-sensing enzymes in integrative physiology. We investigated the effect of both genetic deficiency and pharmacological inhibition on the change in ventilation in response to acute hypoxic stimulation in mice. Mice exposed to ch...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Talbot, NP More by this author
Turner, PJ More by this author
Nicholls, LG More by this author
Pascual, A More by this author
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Journal:
The Journal of physiology
Volume:
591
Issue:
Pt 14
Pages:
3565-3577
Publication date:
2013-07-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:e7a0a303-2207-4975-a103-1539b357c870
Source identifiers:
401239
Local pid:
pubs:401239

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