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Journal article

Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.

Abstract:

Nicotine is the primary psychoactive component of tobacco. Its reinforcing and addictive properties depend on nicotinic acetylcholine receptors (nAChRs) located within the mesolimbic axis originating in the ventral tegmental area (VTA). The roles and oligomeric assembly of subunit α4- and subunit α6-containing nAChRs in dopaminergic (DAergic) neurons are much debated. Using subunit-specific knockout mice and targeted lentiviral re-expression, we have determined the subunit dependence of intra...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1103000108

Authors


Maubourguet, N More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
18
Pages:
7577-7582
Publication date:
2011-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e798f313-faec-4404-bce4-4d741035e1f9
Source identifiers:
134960
Local pid:
pubs:134960

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