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FGFs, their receptors, and human limb malformations: clinical and molecular correlations.

Abstract:

Fibroblast growth factors (FGFs) comprise a family of 22 distinct proteins with pleiotropic signaling functions in development and homeostasis. These functions are mediated principally by four fibroblast growth factor receptors (FGFRs), members of the receptor tyrosine kinase family, with heparin glycosaminoglycan as an important cofactor. Developmental studies in chick and mouse highlight the critical role of FGF-receptor signaling in multiple phases of limb development, including the positi...

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Publication status:
Published

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Publisher copy:
10.1002/ajmg.10775

Authors


Wilkie, AO More by this author
van den Ouweland, AM More by this author
Journal:
American journal of medical genetics
Volume:
112
Issue:
3
Pages:
266-278
Publication date:
2002-10-05
DOI:
EISSN:
1096-8628
ISSN:
0148-7299
URN:
uuid:e78df366-024e-4aaf-b93a-189dae0c8f74
Source identifiers:
119904
Local pid:
pubs:119904

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