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Journal article

Radiosensitivity of colorectal cancer to 90Y and the radiobiological implications for radioembolisation therapy

Abstract:

Approximately 50% of all colorectal cancer (CRC) patients will develop metastasis to the liver. 90Y selective internal radiation therapy (SIRT) is an established treatment for metastatic CRC. There is still a fundamental lack of understanding regarding the radiobiology underlying the dose response. This study was designed to determine the radiosensitivity of two CRC cell lines (DLD-1 and HT-29) to 90Y β− radiation exposure, and thus the relative effectiveness of 90Y SIRT in relation to extern...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1088/1361-6560/ab23c4

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More from this funder
Name:
Cancer Research UK
Grant:
22906
Publisher:
IOP Publishing
Journal:
Physics in Medicine and Biology More from this journal
Volume:
64
Issue:
13
Article number:
135018
Publication date:
2019-07-05
Acceptance date:
2019-05-22
DOI:
EISSN:
1361-6560
ISSN:
0031-9155
Keywords:
Pubs id:
pubs:1002880
UUID:
uuid:e754bc20-9125-4726-b5cd-8455f239ba3e
Local pid:
pubs:1002880
Source identifiers:
1002880
Deposit date:
2019-05-24

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