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Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission.

Abstract:

Cytokinesis requires a membrane-remodeling and fission event termed abscission that occurs after chromosome segregation, cleavage furrow formation, and contraction have completed. In this study, we show how abscission factor recruitment is controlled by the Polo-like kinase 1 (Plk1). At the metaphase-anaphase transition, Plk1 initiates cleavage furrow formation and is then progressively degraded during mitotic exit. During this period, Plk1 phosphorylates the abscission factor Cep55 in trans ...

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Publisher copy:
10.1083/jcb.201008108

Authors


Bastos, RN More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
The Journal of cell biology
Volume:
191
Issue:
4
Pages:
751-760
Publication date:
2010-11-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:e74c9f30-9a50-4c32-aa56-aefd69cf35c0
Source identifiers:
310260
Local pid:
pubs:310260

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