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Synthetic post-translational modification of histones

Abstract:

Chromatin is the physiological template of genetic information in all eukaryotic cells, a highly organised complex of DNA and histone proteins central in regulating gene expression and genome organisation. A multitude of histone post-translational modifications (PTMs) have been discovered, providing a glance into the complex interplay of these epigenetic marks in cellular processes. In the last decade, synthetic and chemical biology techniques have emerged to study these modifications, includ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.cbpa.2018.02.004

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Chemical Biology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Physical & Theoretical Chem
ORCID:
0000-0003-2640-9560
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Pembroke College
ORCID:
0000-0002-5056-407X
Felix Foundation More from this funder
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Chemical Biology Journal website
Volume:
45
Pages:
35-47
Publication date:
2018-02-28
Acceptance date:
2018-02-10
DOI:
EISSN:
1879-0402
ISSN:
1367-5931
Pubs id:
pubs:828160
URN:
uri:e72edecf-806a-4002-848d-a988b33fe0c0
UUID:
uuid:e72edecf-806a-4002-848d-a988b33fe0c0
Local pid:
pubs:828160
Language:
English

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