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Journal article

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.

Abstract:

FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targets such as Notch1, c-Jun, and cyclin E that function in critical developmental and signalling pathways. Mutations in FBXW7 are often found in many types of cancer. In most cases, these mutations do not inactivate the protein, but are mono-allelic missense changes at specific arginine resides involved in substrate binding. We have hypothesized that FBXW7 mutations are selected in cancers for re...

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Publication status:
Published

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Publisher copy:
10.1002/path.2874

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Journal:
Journal of pathology More from this journal
Volume:
224
Issue:
2
Pages:
180-189
Publication date:
2011-06-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Pubs id:
pubs:134964
UUID:
uuid:e70e14ae-fcc2-432e-97bb-a8b36092e116
Local pid:
pubs:134964
Source identifiers:
134964
Deposit date:
2012-12-19

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