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Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of hospital admission

Abstract:
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/ofid/ofac179

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author

Contributors


More from this funder
Grant:
215091/Z/18/Z
OPP1209135


Publisher:
Oxford University Press
Journal:
Open Forum Infectious Diseases More from this journal
Volume:
9
Issue:
5
Article number:
ofac179
Publication date:
2022-05-01
Acceptance date:
2022-04-01
DOI:
EISSN:
2328-8957


Language:
English
Keywords:
Pubs id:
1268802
Local pid:
pubs:1268802
Deposit date:
2022-07-25

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