Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

Wensley, F; Gao, P; Burgess, S; Kaptoge, S; Di Angelantonio, E; Shah, T; Engert, JC; Clarke, R; Davey-Smith, G; Nordestgaard, BG; Saleheen, D; Samani, NJ; Sandhu, M; Anand, S; Pepys, MB; Smeeth, L; Whittaker, J; Casas, JP; Thompson, SG; Hingorani, AD; Danesh, J; Eiriksdottir, G; Harris, TB; Launer, LJ; Gudnason, V; Folsom, AR; Andrews, G; Ballantyne, CM; Samani, NJ; Hall, AS; Braund, PS; Balmforth, AJ; Whincup, PH; Morris, R; Lawlor, DA; Lowe, GDO; Timpson, N; Ebrahim, S; Ben-Shlomo, Y; Davey-Smith, G; Timpson, N; Nordestgaard, BG; Tybjaerg-Hansen, A; Zacho, J; Brown, M; Sandhu, M; Ricketts, SL; Ashford, S; Lange, L; Reiner, A; Cushman, M; Tracy, R; Wu, C; Ge, J; Zou, Y; Sun, A; Hung, J; McQuillan, B; Thompson, P; Beilby, J; Warrington, N; Palmer, LJ; Wanner, C; Drechsler, C; Hoffmann, MM; Fowkes, FGR; Lowe, GDO; Tzoulaki, I; Kumari, M; Miller, M; Marmot, M; Onland-Moret, C; van der Schouw, YT; Boer, JM; Wijmenga, C; Ricketts, SL; Ashford, S; Sandhu, M; Khaw, K-T; Vasan, RS; Schnabel, RB; Yamamoto, JF; Benjamin, EJ; Schunkert, H; Erdmann, J; Koenig, IR; Hengstenberg, C; Chiodini, B; Franzosi, MG; Pietri, S; Gori, F; Rudock, M; Liu, Y; Lohman, K; Harris, TB; Humphries, SE; Hamsten, A; Norman, PE; Hankey, GJ; Jamrozik, K; Palmer, LJ; Rimm, EB; Pai, JK; Psaty, BM; Heckbert, SR; Bis, JC; Yusuf, S; Anand, S; Engert, JC; Xie, C; Collins, R; Clarke, R; Bennett, D; Kooner, J; Chambers, J; Elliott, P; Maerz, W; Kleber, ME; Boehm, BO; Winkelmann, BR; Melander, O; Berglund, G; Koenig, W; Thorand, B; Baumert, J; Peters, A; Rimm, EB; Manson, J; Pai, JK; Humphries, SE; Cooper, JA; Talmud, PJ; Ladenvall, P; Johansson, L; Jansson, J-H; Hallmans, G; Reilly, MP; Qu, L; Li, M; Rader, DJ; Watkins, H; Clarke, R; Hopewell, J; Saleheen, D; Danesh, J; Frossard, P; Sattar, N; Robertson, M; Shepherd, J; Schaefer, E; Hofman, A; Witteman, JCM; Kardys, I; Dehghan, A; de Faire, U; Bennet, A; Gigante, B; Leander, K; Ben-Shlomo, Y; Davey-Smith, G; Timpson, N; Peters, B; Maitland-van der Zee, AH; de Boer, A; Klungel, O; Reiner, A; Manson, J; Greenland, P; Dai, J; Liu, S; Kumari, M; Brunner, E; Kivimaki, M; Marmot, M; Sattar, N; O'Reilly, D; Ford, I; Packard, CJ; Dis, CRPCH; AGES; ARIC; BHF-FHS; BRHS; BWHHS; CAPS; CIHDS, CC; CHAOS; CHS; CRPHANS; CUPID, C; 4D; EAS; ELSA; EPICNL; EPICNOR; FRAMOFF; GERMIFS; GISSI-P; HEALTHABC; HIFMECH; HIMS; HPFS; HVHS; INTERHEART; ISIS; LOLIPOP; LURIC; MALMO; MONICAKORA; NHS; NPHSII; NSC; PENNCATH; PROCARDIS; PROMIS; PROSPER; ROTTERDAM; SHEEP; SPEED; UCP; WHIOS; WHITEII; WOSCOPS

Abstract:

To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease. Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries. 194418 participants, including 46557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C r...

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APA Style

Wensley, F., Gao, P., Burgess, S., Kaptoge, S., Di Angelantonio, E., Shah, T., Engert, J. C., Clarke, R., Davey-Smith, G., Nordestgaard, B. G., Saleheen, D., Samani, N. J., Sandhu, M., Anand, S., Pepys, M. B., Smeeth, L., Whittaker, J., Casas, J. P., Thompson, S. G., … WOSCOPS. (2011). Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BRITISH MEDICAL JOURNAL, 342(feb15 2), d548–d548.

MLA Style

Wensley, F., et al. “Association between C Reactive Protein and Coronary Heart Disease: Mendelian Randomisation Analysis Based on Individual Participant Data.” BRITISH MEDICAL JOURNAL, vol. 342, no. feb15 2, 2011, pp. d548–d548.

Chicago Style

Wensley, F, P Gao, S Burgess, S Kaptoge, E Di Angelantonio, T Shah, JC Engert, et al. 2011. “Association between C Reactive Protein and Coronary Heart Disease: Mendelian Randomisation Analysis Based on Individual Participant Data.” BRITISH MEDICAL JOURNAL 342 (feb15 2): d548–d548.
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