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Real-time dynamic modelling for the design of a cluster-randomized phase 3 Ebola vaccine trial in Sierra Leone

Abstract:

Background

Declining incidence and spatial heterogeneity complicated the design of phase 3 Ebola vaccine trials during the tail of the 2013–16 Ebola virus disease (EVD) epidemic in West Africa. Mathematical models can provide forecasts of expected incidence through time and can account for both vaccine efficacy in participants and effectiveness in populations. Determining expected disease incidence was critical to calculating power and determining trial sample size.

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-0023-3985
More by this author
Role:
Author
ORCID:
0000-0002-0362-6717
More from this funder
Name:
Norwegian Institute of Public Health
Funding agency for:
Watson, C
Publisher:
Elsevier
Journal:
Vaccine More from this journal
Volume:
35
Issue:
4
Pages:
544-551
Publication date:
2016-12-23
Acceptance date:
2016-12-12
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pmid:
28024952
Language:
English
Keywords:
Pubs id:
pubs:997736
UUID:
uuid:e7011cb0-dd0a-4163-9010-e61a73c41b3a
Local pid:
pubs:997736
Source identifiers:
997736
Deposit date:
2019-05-29

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