Journal article icon

Journal article

Methylation of two Homo sapiens-specific X-Y homologous genes in Klinefelter's syndrome (XXY).

Abstract:

An increased incidence of psychiatric and structural brain abnormalities in individuals with Klinefelter syndrome (KS, 47 XXY) could be due to the presence of extra copies of X-Y homologous genes that escape X inactivation. Of particular interest are the two brain-expressed genes Protocadherin11XY (PCDH11XY) and the Synaptobrevin-like gene (SYBL1) which have been duplicated from the X chromosome to the Y chromosome to give X-Y homologous gene pairs that are specific to modern humans. We exami...

Expand abstract

Actions


Access Document


Publisher copy:
10.1002/ajmg.b.30339

Authors


Expand authors...
Journal:
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Volume:
141B
Issue:
5
Pages:
544-548
Publication date:
2006-07-05
DOI:
EISSN:
1552-485X
ISSN:
1552-4841
URN:
uuid:e6f7523d-e07c-4827-be48-7ba914e07d30
Source identifiers:
470826
Local pid:
pubs:470826

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP