- Abstract:
-
Polymorphisms in the gene for the α5 nicotinic acetylcholine receptor (nAChR) subunit are associated with vulnerability to nicotine addiction. However, the underlying normal functions of α5-containing nAChRs in the brain are poorly understood. Striatal dopamine (DA) transmission is critical to the acquisition and maintenance of drug addiction and is modulated strongly by nicotine acting at heteromeric β2-containing (β2*) nAChRs. We explored whether α5 subunits, as well as α4, α6, and β3 subun...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1523/jneurosci.4985-11.2012
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- Journal:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Volume:
- 32
- Issue:
- 7
- Pages:
- 2352-2356
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
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1529-2401
- ISSN:
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0270-6474
- URN:
-
uuid:e6f02abe-b899-4add-a6a4-f6803a55d83b
- Source identifiers:
-
316393
- Local pid:
- pubs:316393
- Copyright date:
- 2012
Journal article
Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.
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