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Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.

Abstract:

Polymorphisms in the gene for the α5 nicotinic acetylcholine receptor (nAChR) subunit are associated with vulnerability to nicotine addiction. However, the underlying normal functions of α5-containing nAChRs in the brain are poorly understood. Striatal dopamine (DA) transmission is critical to the acquisition and maintenance of drug addiction and is modulated strongly by nicotine acting at heteromeric β2-containing (β2*) nAChRs. We explored whether α5 subunits, as well as α4, α6, and β3 subun...

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Publication status:
Published

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Authors


McIntosh, JM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
32
Issue:
7
Pages:
2352-2356
Publication date:
2012-02-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:e6f02abe-b899-4add-a6a4-f6803a55d83b
Source identifiers:
316393
Local pid:
pubs:316393

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