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The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage

Abstract:

Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ, the mechanism regulating Ku ubiquitylation remains elusive. We provide evidence showing that the ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) interacts with and directly deu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-018-36235-0

Authors


Wijnhoven, PWG More by this author
Konietzny, R More by this author
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Publisher:
Springer Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Publication date:
2018-12-17
Acceptance date:
2018-11-16
DOI:
EISSN:
2045-2322
Pubs id:
pubs:953233
URN:
uri:e6ebad20-8329-428b-bfce-87b1ea2282b3
UUID:
uuid:e6ebad20-8329-428b-bfce-87b1ea2282b3
Local pid:
pubs:953233
Language:
English

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