Journal article icon

Journal article

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage

Abstract:

Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ, the mechanism regulating Ku ubiquitylation remains elusive. We provide evidence showing that the ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) interacts with and directly deu...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41598-018-36235-0

Authors


Publisher:
Springer Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
8
Publication date:
2018-12-17
Acceptance date:
2018-11-16
DOI:
EISSN:
2045-2322
Language:
English
Pubs id:
pubs:953233
UUID:
uuid:e6ebad20-8329-428b-bfce-87b1ea2282b3
Local pid:
pubs:953233
Source identifiers:
953233
Deposit date:
2018-12-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP