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In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging.

Abstract:

RATIONALE AND OBJECTIVE: Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. We hypothesized that microparticles of iron oxide targeting VCAM-1 (VCAM-MPIO) would depict "ischemic memory" and enable in vivo assessment of VCAM-1 expression. METHODOLOGY AND FINDINGS: Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg bod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0012800

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Schneider, J
Grant:
BS/06/001
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Funding agency for:
Wood, K
Grant:
082519
British Heart Foundation More from this funder
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Funding agency for:
Choudhury, R
Grant:
088291
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
9
Article number:
e12800
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
83819
Language:
English
Keywords:
UUID:
uuid:e6e8bc7d-b677-4cb3-99e6-e17c7f8cb4ed
Local pid:
pubs:83819
Deposit date:
2012-12-19

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