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In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging.

Abstract:

RATIONALE AND OBJECTIVE: Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. We hypothesized that microparticles of iron oxide targeting VCAM-1 (VCAM-MPIO) would depict "ischemic memory" and enable in vivo assessment of VCAM-1 expression. METHODOLOGY AND FINDINGS: Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg bod...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0012800

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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Funding agency for:
Schneider, JE
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Funding agency for:
Wood, KJ
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Funding agency for:
Choudhury, RP
Wellcome Trust More from this funder
British Heart Foundation More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
9
Pages:
Article: e12800
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:e6e8bc7d-b677-4cb3-99e6-e17c7f8cb4ed
Source identifiers:
83819
Local pid:
pubs:83819

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