Journal article icon

Journal article

Typing complex meningococcal vaccines to understand diversity and population structure of key vaccine antigens

Abstract:

Background: Protein-conjugate capsular polysaccharide vaccines can potentially control invasive meningococcal disease (IMD) caused by five (A, C, W, X, Y) of the six IMD-associated serogroups.  Concerns raised by immunological similarity of the serogroup B capsule, to human neural cell carbohydrates, has meant that ‘serogroup B substitute’ vaccines target more variable subcapsular protein antigens.  A successful approach using outer membrane vesicles (OMVs) as major vaccine components had lim...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Role:
Author
ORCID:
0000-0003-0942-3707
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
ORCID:
0000-0002-0751-0287
Publisher:
F1000Research
Journal:
Wellcome Open Research More from this journal
Volume:
3
Pages:
151
Publication date:
2019-03-12
Acceptance date:
2019-01-14
DOI:
ISSN:
2398-502X
Language:
English
Keywords:
Pubs id:
pubs:951450
UUID:
uuid:e6e6bb25-7833-4fcc-be18-6e34e7c7bc7b
Local pid:
pubs:951450
Source identifiers:
951450
Deposit date:
2019-02-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP