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Severe Achromobacter xylosoxidans infection and loss of sputum bacterial diversity in an adult patient with cystic fibrosis

Abstract:
Achromobacter spp. are emerging pathogens in the lungs of patients with cystic fibrosis. We report the case of an adult patient with cystic fibrosis and chronic A. xylosoxidans infection who experienced rapid, progressive clinical deterioration. Metagenomic analysis of the sputum revealed that the airway microbiota was almost entirely dominated by A. xylosoxidans. We review the impact of this organism on lung function and the airway microbiome in cystic fibrosis, and discuss the potential for cross-infection between patients.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.prrv.2016.06.011

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Strategic
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Paediatric Respiratory Reviews Journal website
Volume:
20
Issue:
S
Pages:
27-29
Publication date:
2016-06-14
Acceptance date:
2016-06-09
DOI:
EISSN:
1526-0550
ISSN:
1526-0542
Source identifiers:
628092
Keywords:
Pubs id:
pubs:628092
UUID:
uuid:e6d08361-d93d-4fa0-8403-30a924806e3b
Local pid:
pubs:628092
Deposit date:
2016-06-16

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