Journal article

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Abstract:: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger receptor low density lipoprotein receptor-related protein 1 (LRP1). Here, we used molecular modeling to predict TIMP-3 residues potentially involved in binding to LRP1 based on the proposed LRP1 bi...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Doherty, C., Visse, R., Dinakarpandian, D., Strickland, D., Nagase, H., & Troeberg, L. (2016). Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity. Journal of Biological Chemistry, 291(42), 22160–22172.

MLA Style

Doherty, C., et al. “Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.” Journal of Biological Chemistry, vol. 291, no. 42, American Society for Biochemistry and Molecular Biology, 2016, pp. 22160–72.

Chicago Style

Doherty, C, R Visse, D Dinakarpandian, D Strickland, H Nagase, and L Troeberg. 2016. “Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.” Journal of Biological Chemistry 291 (42): 22160–72.
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Files:: J. Biol. Chem.-2016-Doherty-22160-72.pdf

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Publisher copy:: 10.1074/jbc.M116.733261

Authors

+ Doherty, C More by this author

Role:

Author

+ Visse, R More by this author

Role:

Author

+ Dinakarpandian, D More by this author

Role:

Author

+ Strickland, D More by this author

Role:

Author

+ Nagase, H More by this author

Role:

Author

More authors...

Funding

+ Arthritis Research UK More from this funder

Funding agency for:

Troeberg, L

Grant:

19466

20205

+ National Institutes of Health More from this funder

Grant:

HL120388

+ National Heart, Lung and Blood Institutes More from this funder

Grant:

HL120388

+ National Institute of Arthritis and Musculoskeletal and Skin Diseases More from this funder

Grant:

AR40994

+ Kennedy Trust for Rheumatology Research More from this funder

Bibliographic Details

Publisher:: American Society for Biochemistry and Molecular Biology
Journal:: Journal of Biological Chemistry More from this journal
Volume:: 291
Issue:: 42
Pages:: 22160-22172
Publication date:: 2016-08-31
Acceptance date:: 2016-08-31
DOI:: 10.1074/jbc.M116.733261
ISSN:: 1083-351X

Item Description

Keywords:: low-density lipoprotein receptor-related protein 1 (LRP1)

receptor endocytosis

ADAM

ADAMTS

osteoarthritis

tissue inhibitor of metalloproteinase (TIMP)

glycosaminoglycan

extracellular matrix
Pubs id:: pubs:641561
UUID:: uuid:e6c76577-6e9e-4b2b-98c3-ed00c5e9d3db
Local pid:: pubs:641561
Source identifiers:: 641561
Deposit date:: 2016-09-05

Terms of use

Copyright holder:: American Society for Biochemistry and Molecular Biology
Copyright date:: 2016
Notes:: Copyright © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Under a Creative Commons CC-BY license.

Licence:: CC Attribution (CC BY)

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