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Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity

Abstract:

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger receptor low density lipoprotein receptor-related protein 1 (LRP1). Here, we used molecular modeling to predict TIMP-3 residues potentially involved in binding to LRP1 based on the proposed LRP1 bi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.M116.733261

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Funding agency for:
Troeberg, L
Grant:
19466
Kennedy Trust for Rheumatology Research More from this funder
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
291
Issue:
42
Pages:
22160-22172
Publication date:
2016-08-31
Acceptance date:
2016-08-31
DOI:
ISSN:
1083-351X
Source identifiers:
641561
Keywords:
Pubs id:
pubs:641561
UUID:
uuid:e6c76577-6e9e-4b2b-98c3-ed00c5e9d3db
Local pid:
pubs:641561
Deposit date:
2016-09-05

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