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A modular platform for one-step assembly of multi-component membrane systems by fusion of charged proteoliposomes

Abstract:

An important goal in synthetic biology is the assembly of biomimetic cell-like structures, which combine multiple biological components in synthetic lipid vesicles. A key limiting assembly step is the incorporation of membrane proteins into the lipid bilayer of the vesicles. Here we present a simple method for delivery of membrane proteins into a lipid bilayer within 5 min. Fusogenic proteoliposomes, containing charged lipids and membrane proteins, fuse with oppositely charged bilayers, with ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms13025

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Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Russell, AN More by this author
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Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
Article: 13025
Publication date:
2016-10-06
Acceptance date:
2016-08-25
DOI:
ISSN:
2041-1723
Pubs id:
pubs:648241
URN:
uri:e6c2fd1b-1d72-416c-8d20-ce959d4fd5bd
UUID:
uuid:e6c2fd1b-1d72-416c-8d20-ce959d4fd5bd
Local pid:
pubs:648241

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