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A modular platform for one-step assembly of multi-component membrane systems by fusion of charged proteoliposomes

Abstract:

An important goal in synthetic biology is the assembly of biomimetic cell-like structures, which combine multiple biological components in synthetic lipid vesicles. A key limiting assembly step is the incorporation of membrane proteins into the lipid bilayer of the vesicles. Here we present a simple method for delivery of membrane proteins into a lipid bilayer within 5 min. Fusogenic proteoliposomes, containing charged lipids and membrane proteins, fuse with oppositely charged bilayers, with ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms13025

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
More from this funder
Funding agency for:
Ishmukhametov, R
Grant:
BB/L01985X/1
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Article number:
13025
Publication date:
2016-10-06
Acceptance date:
2016-08-25
DOI:
ISSN:
2041-1723
Source identifiers:
648241
Pubs id:
pubs:648241
UUID:
uuid:e6c2fd1b-1d72-416c-8d20-ce959d4fd5bd
Local pid:
pubs:648241
Deposit date:
2016-10-06

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