Journal article
Senescence of T Lymphocytes: Implications for Enhancing Human Immunity
- Abstract:
- As humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. It is therefore crucial to understand the mechanisms responsible for this decrease in immunity and to develop new strategies to enhance immune function in older humans. We discuss here how the induction of senescence alters leukocyte, and specifically T cell, function. An emerging concept is that senescence and nutrient sensing-signalling pathways within T cells converge to regulate functional responses, and the manipulation of these pathways may offer new ways to enhance immunity during ageing.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 442.6KB, Terms of use)
-
- Publisher copy:
- 10.1016/j.it.2016.09.002
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Immunology More from this journal
- Volume:
- 37
- Issue:
- 12
- Pages:
- 866-876
- Publication date:
- 2016-10-04
- Acceptance date:
- 2016-01-01
- DOI:
- EISSN:
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1471-4981
- ISSN:
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1471-4906
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:652931
- UUID:
-
uuid:e6b5abbd-83e2-4c0e-acc9-956c9ad37727
- Local pid:
-
pubs:652931
- Source identifiers:
-
652931
- Deposit date:
-
2016-11-02
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2016
- Notes:
- © 2016 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: [10.1016/j.it.2016.09.002].
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