- Abstract:
-
The tetrameric GINS complex, consisting of Sld5-Psf1-Psf2-Psf3, plays an essential role in the initiation and elongation steps of eukaryotic DNA replication, although its biochemical function is unclear. Here we investigate the function of GINS in fission yeast, using fusion of Psf1 and Psf2 subunits to a steroid hormone-binding domain (HBD) to make GINS function conditional on the presence of beta-estradiol. We show that inactivation of Psf1-HBD causes a tight but rapidly reversible DNA repl...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1091/mbc.e08-04-0429
-
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- Journal:
- Molecular biology of the cell
- Volume:
- 20
- Issue:
- 4
- Pages:
- 1213-1222
- Publication date:
- 2009-02-05
- DOI:
- EISSN:
-
1939-4586
- ISSN:
-
1059-1524
- URN:
-
uuid:e6b2834e-5449-4fb4-8947-caa00f38b03f
- Source identifiers:
-
209224
- Local pid:
- pubs:209224
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.
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